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|Mol Wt:||16 KDa||Applications:||WB,IHC-p,IF,ELISA|
|Clonallity:||Clonallity: Polyclonal||Protein Name:||3-phosphoinositide-dependent Protein Kinase 1|
TNF Rabbit Polyclonal Antibody
Cat.No. BT-AP06654 Size: 100ul/50ul/20ul Datasheet Request
Immunogen: Synthesized peptide derived from human PDK1 around the non-phosphorylation site of Y9
Protein Name: 3-phosphoinositide-dependent protein kinase 1
Species reactivity: human, mouse, rat
Observed band: 16 kDa
Concentration: 1 mg/ml
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
The antibody was affinity-purified from rabbit antiserum byaffinity-chromatography using epitope-specific immunogen.
TNF-alpha; APC1; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNF-a; TNF alpha; TNF; TNF Macrophage Derived; TNF Monocyte Derived; TNF Superfamily Member 2; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor Precursor; Tumour Necrosis Factor Alpha; TNFSF1A; TNFA_HUMAN.
IF: 1: 200 - 1: 1000
IHC: 1: 100 - 1: 300
ELISA: 1: 10000
Not yet tested in other applications
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Contact Person: Lee
Reactivity: human, mouse, rat
Synonyms: TNF-alpha; APC1; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNF-a; TNF alpha; TNF; TNF Macrophage Derived; TNF Monocyte Derived; TNF Superfamily Member 2; TNFA; TNFSF2; Tumor necrosis factor ligand superfam