Mouse Anti PKB Monoclonal Antibodies , 1 mg/ml Concentration Mab Monoclonal

Highly sensitive and specific Mouse Anti PKB Monoclonal Antibody

Cat.No. BT-MCA0023 Size: 20ul/50ul/100ul Datasheet Request

Product Information

Clonallity: Monoclonal

Source: mouse

Isotype: IgG

Protein Name: AKT1

Immunogen: KLH conjugated synthetic peptide derived from human AKT

Synonyms: AKT 1; AKT; AKT1; AKT-1; AKT1_HUMAN; C AKT; cAKT; MGC9965; MGC99656; Oncogene AKT1; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC alpha serine/threonine protein kinase; RAC; RAC PK Alpha; Rac protein kinase alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; v akt murine thymoma viral oncogene homolog 1; vAKT Murine Thymoma Viral Oncogene Homolog 1.

Species specificity: human, mouse, rat

Recommended Dilution:

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.

Background

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.