Sensitive Rabbit Anti RPD3 Monoclonal Antibodies with 1 mg/ml Concentration

Highly sensitive and specific Rabbit Anti RPD3 Monoclonal Antibody

Cat.No. BT-MCA0354  Size: 20ul/50ul/100ul Datasheet Request

Product Information

Clonallity: Monoclonal

Source: mouse

Isotype: IgG

Protein Name: HDAC1

Immunogen: KLH conjugated synthetic peptide derived from human HDAC1

Species specificity: Human, Mouse, Rat

Recommended Dilution:

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.

Background

Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.